Myalgic encephalomyelitis (ME), also referred to in the literature as chronic fatigue syndrome (CFS), is a complex disease involving profound disregulation of the central nervous system (CNS)[1-3] and immune system [4-8], dysfunction of cellular energy metabolism and ion transport [9-11], and cardiovascular abnormalities [12-14]. (Myalgic Encephalomyelitis: International Concensus Criteria)

The consequences of this disease are devastating if not diagnosed and treated early, leading to chronic impairments affecting daily activities functioning, independence, quality of life, and adding to the total health bill due to lost productivity.

These findings are supported by research and a comprehensive list can also be found in the articles below.

Myalgic Encephalomyelitis: International Consensus Criteria

Abnormal impedance cardiography predicts symptom severity in Chronic Fatigue Syndrome

Chronic fatigue syndrome and mitochondrial dysfunction

Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects.

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.

Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging.

Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study.

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms

Bacterial and Viral Co-Infections in Chronic Fatigue Syndrome (CFS/ME) Patients

A Pediatric Case Definition for ME/CFS by Leonard Jason 2006

Reporting of Harms Associated with Graded Exercise Therapy and Cognitive, Behavioural Therapy in ME/CFS

Long term sickness absence due to ME/CFS in UK schools An Epidemiological Study