References

Myalgic encephalomyelitis (ME), also referred to in the literature as chronic fatigue syndrome (CFS), is a complex disease involving profound disregulation of the central nervous system (CNS)[1-3] and immune system [4-8], dysfunction of cellular energy metabolism and ion transport [9-11], and cardiovascular abnormalities [12-14]. (Myalgic Encephalomyelitis: International Concensus Criteria)

The consequences of this disease are devastating if not diagnosed and treated early, leading to chronic impairments affecting daily activities functioning, independence, quality of life, and adding to the total health bill due to lost productivity.

These findings are supported by research and a comprehensive list can also be found in the articles below.

Myalgic Encephalomyelitis: International Consensus Criteria

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02428.x/full

Abnormal impedance cardiography predicts symptom severity in Chronic Fatigue Syndrome
http://www.ncbi.nlm.nih.gov/pubmed/12920435

Chronic fatigue syndrome and mitochondrial dysfunction
http://www.ijcem.com/files/IJCEM812001.pdf

Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects.
http://www.ncbi.nlm.nih.gov/pubmed/19647494

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/21615807

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.
http://www.ncbi.nlm.nih.gov/pubmed/16494597

Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging.
http://www.ncbi.nlm.nih.gov/pubmed/21793948

Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study.
http://www.ncbi.nlm.nih.gov/pubmed/22039471

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
http://www.translational-medicine.com/content/9/1/81

Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms
http://www.immed.org/Fatigue%20Illness/NicolsonAPMIS419.pdf

Bacterial and Viral Co-Infections in Chronic Fatigue Syndrome (CFS/ME) Patients
http://www.immed.org/Fatigue%20Illness/Netal_co_MycoAust02%5B1%5D.1.rtf

A Pediatric Case Definition for ME/CFS by Leonard Jason 2006
http://www.iacfsme.org/Portals/0/pdf/pediatriccasedefinitionshort.pdf

Reporting of Harms Associated with Graded Exercise Therapy and Cognitive, Behavioural Therapy in ME/CFS
http://www.iacfsme.org/LinkClick.aspx?fileticket=Rd2tIJ0oHqk%3d&tabid=501

Long term sickness absence due to ME/CFS in UK schools An Epidemiological Study
http://www.tymestrust.org/pdfs/dowsettcolby.pdf